PE is one of the most common male sexual dysfunctions, affecting nearly one in three men worldwide between the ages of 18 and 59 years. Premature ejaculation (PE) and its individual and relationship consequences have been recognized in the literature for centuries. The predominant action of local anaesthetics is to reduce neuronal firing in sensory afferents the clinical profile of PSD502, which shows improvement of ejaculatory function in the absence of a generalized reduction in penile sensitivity, can most readily be explained based on an underlying hypersensitivity in patients with PE. The clinical profile of PSD502 lends credibility to the penile hypersensitivity hypothesis for PE. Data from the PSD502 clinical trials clearly shows that PSD502 increases ejaculatory latency, and improves control and sexual satisfaction when applied topically to men with PE 5 min before intercourse, enabling subjects to delay ejaculation up to six times longer than those who used a placebo. Interpretation of the data is hampered by the variability of the populations described as having PE across studies.
The published data does not support unequivocally penile hypersensitivity as the cause of PE. The clinical profile of PSD502, based on its local anaesthetic properties, is used as a surrogate index of the role of sensory afferents in the ejaculatory reflex.
#Karma sutra diagrams pdf download trial#
Historical neurophysiological data was reviewed, together with data from the recent PSD502 clinical trials, including the first published double-blind clinical trial data evaluating a topical desensitizing agent in a population of men with PE, as per the new ISSM definition. PSD502 is a eutectic-like mixture of two local anaesthetics, lidocaine and prilocaine, whose primary action is to reduce neuronal conduction in sensory afferents. Penile hypersensitivity as a cause of PE is based on historical clinical neurophysiological data and clinical efficacy of the topical desensitizing agent PSD502 in the treatment of PE. To investigate the correlation between penile hypersensitivity and premature ejaculation (PE), as defined by the criteria identified by the International Society of Sexual Medicine (ISSM). In addition, it will engage all those interested in learning more about how the sex trade operates in Bangladesh. An accessible and compelling read, this will appeal to students and scholars of criminology, sociology, gender studies, south Asian studies, cultural studies, social theory, and policy makers.
It argues that the lived experience of sex workers comprises both victimhood and agency, deception and resilience, and that it is the management of these relationships that enable sex works to avoid social marginalization and alienation. Towards a Southern Approach to Sex Work contributes to feminist scholarship on sex work, by offering a much needed Southern perspective, drawing on culturally specific data. Drawing onįeminist frameworks, it shows that the experiences of sex workers vary widely depending on the ways they enter the sex trade, their modes of operation, and relationships with significant others. Very little about sex work in Asia and the global South. Despite being the mostĬommon form of female deviance and criminality globally, we know Their working conditions and relationships. The lived experiences of sex workers in Bangladesh, considering theĬomplex realities of their day-to-day lives and the ways they negotiate This book delves into this almost unchartered territory, documenting It could be concluded that HoT successfully measured ejaculatory control in men and differentiated normal ejaculators from the premature ejaculators in the sample studied. The construct validity of HoT to diagnose PE was good with 90% sensitivity, 91% specificity, 63.8% positive predictive value, and 98.1% negative predictive value to diagnose PE when compared with diagnosis by a standard tool. Both the normal (r = 0.983) as well as premature ejaculators (r = 0.839) had good test–retest reliability.
The mean HoT in normal ejaculators was 120.2 ± 31.7 s and the same in premature ejaculators was 32.9 ± 12.9 s. The study sample had 10 healthy, sexually active normal ejaculators, and 10 premature ejaculators, who volunteered to participate in the study conducted from May 2020 to April 2021. The construct validity of this tool to differentiate premature ejaculators from normal ejaculators was also assessed in our sample. Hence, we designed a pilot study to validate holding time (HoT), a novel objective tool, hypothesized by us, to measure ejaculatory control in men. However, we cannot objectively estimate ejaculatory control due to the absence of an objective tool to measure it. Premature ejaculation (PE) is considered as a disorder of perceived loss of ejaculatory control.
0 kommentar(er)
